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Antibiotic Zosurabalpin
April 1 , 2024
238 days
428
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- Researchers have identified a new class of antibiotics with the potential to tackle a drug-resistant bacterium, Acinetobacter baumannii.
- Zosurabalpin was found to be effective against CRAB (carbapenem-resistant Acinetobacter baumannii)-induced pneumonia and sepsis in mouse models.
- A. baumannii inhibits a key process, transport of the molecule lipopolysaccharide (LPS), by inhibiting a complex of proteins.
- This complex was essential for transporting LPS to the bacterial surface to create the outer-membrane structure of Gram-negative bacteria.
- Zosurabalpin blocks LPS transport, and the abnormal build-up of LPS in the cell kills the bacterium.
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