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Break down ‘Biofilm Barriers’
November 15 , 2024
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- A team of scientists at the Indian Institute of Science (IISc) has devised a way to break down ‘biofilm barriers’ to aid entry of drugs.
- Most of the disease-causing bacteria secrete the matrix-like layers around themselves called biofilms.
- These biofilms act as thick barriers, limiting the entry of drugs, and helping the bacteria become resistant to antibiotics.
- To break down this biofilm barrier, the team has used an enzyme from the cow’s digestive tract.
- The bovine gut harbours microbial enzymes that digest different kinds of complex polysaccharides, such as cellulose and hemicellulose.
- They found glycoside hydrolases (GH)-B2 successfully broke down biofilms in various lab conditions.
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