TNPSC Thervupettagam

Endogamy - harmful genetic variants

August 8 , 2023 347 days 365 0
  • A new study has found higher frequency of homozygous genotypes in South-Asian populations, most likely as a result of caste, endogamy, and consanguineous sexual unions.
  • Such a frequency could lead to higher risk of genetic disorders.
  • South-Indian and Pakistani subgroups were estimated to have a high degree of inbreeding.
  • The study found stark genetic differences between people from different regions of the subcontinent.
  • Humans typically have two copies of each gene.
  • When an individual has two copies of the same variant, it is called a homozygous genotype.

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