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Mitochondrial Coxiella Effector
April 5 , 2024
234 days
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- The Researchers recently discovered a previously unidentified protein named mitochondrial coxiella effector F (MceF).
- It is an antioxidant protein produced by the Gram-negative intracellular bacterium Coxiella burnetii.
- MceF supports human cell health despite a heavy bacterial load.
- Invading host cells, Coxiella burnetii releases MceF, interacting with glutathione peroxidase 4 (GPX4) in mitochondria.
- This interaction enhances mitochondrial function, preventing cell damage and death associated with pathogen replication in mammalian cells.
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