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TDP1 enzyme
October 18 , 2024
35 days
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- The Scientists from the Indian Association for the Cultivation of Science (IACS), Kolkata, have identified a new therapeutic target by activating a DNA repair enzyme called Tyrosyl-DNA phosphodiesterase 1 (TDP1).
- Current anticancer drugs like Camptothecin, Topotecan, and Irinotecan focus on inhibiting the enzyme Topoisomerase 1 (Top1).
- Cancer cells often develop resistance to these drugs, leading the researchers to explore alternative treatment strategies.
- The researchers have discovered that cancer cells can survive Top1-targeted chemotherapy by activating TDP1, which helps repair damaged DNA during cell division.
- This process allows the cancer cells to counteract the effects of chemotherapy and continue proliferating.
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