The Indian Institute of Technology (IIT), Kanpur team identifies a novel target - DLX1 gene - to treat prostate cancer.
The team has discovered that the DLX1 gene has an important role to play in the growth and development of prostate cancer.
When the team genetically removed the DLX1 gene that produces the protein, the ability of cancer cells to grow, develop and spread to other parts of the body was compromised.
The team has further shown that both androgen receptor and fusion gene product ‘ERG’ are responsible for increased levels of DLX1 in prostate cancer cells.
The team also found that Bromodomain and extra terminal (BET) protein assists the function of both androgen receptor and ERG.